Article
Pharmacogenetic-based strategy using de novo tacrolimus once daily after kidney transplantation: prospective pilot study.
Pharmacogenomics - 1 Jun 2016
De Meyer Martine, Haufroid Vincent, Kanaan Nada, Darius Tom, Buemi Antoine, De Pauw Luc, Eddour Djamila Chaïb, Wallemacq Pierre, Mourad Michel
Abstract excerpt
AIM: The once daily tacrolimus formulation (Tac-OD) has been associated with better patient adherence and low variability in exposure. Patients carrying the CYP3A5*1 allele show accelerated clearance of Tac. Authors prospectively evaluate a simplified strategy for Tac-OD administration. PATIENTS & METHODS: After grafting, 151 patients were divided into four groups and received a daily dose calculated according to...
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