Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2011

Xiao Lan, O'Callaghan James P, O'Donnell James M

Abstract excerpt

The effects of repeated treatment with the phosphodiesterase-4 (PDE4) inhibitors rolipram, piclamilast, and 4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine (CDP840), which differ in their interactions with high- and low-affinity binding conformers of the enzyme, were contrasted to those of acute treatment on cAMP signaling, hippocampal cell proliferation, and immobility in the forced-swim test in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cell Survival

Share to Cyclic AMP

Share to Hippocampus

Share to Rats, Sprague-Dawley

Share to Swimming

Source

Open in PubMed Open full text

Identifiers

PMID: 21566211
DOI: 10.1124/jpet.111.179358
PMCID: PMC3141907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test.PMID 21566211Read ↗

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.Semantic proximity Read ↗

RNA interference‐mediated phosphodiesterase 4D splice variants knock‐down in the prefrontal cortex produces antidepressant‐like and cognition‐enhancing effectsSemantic proximity Read ↗

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.Semantic proximity Read ↗

A new model of <i>Pde4d</i> deficiency: genetic knock‐down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effectsSemantic proximity Read ↗

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsySemantic proximity Read ↗

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).Semantic proximity Read ↗

HBK-15 bypasses BDNF via ERK1/2-biased 5-HT1A receptor signaling to deliver a rapid antidepressant-like effectSemantic proximity Read ↗

Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.Semantic proximity Read ↗

Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.Semantic proximity Read ↗

Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior.Semantic proximity Read ↗

PDE11A negatively regulates lithium responsivity.Semantic proximity Read ↗

Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.