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Article

PDE11A negatively regulates lithium responsivity.

Molecular psychiatry - 1 Dec 2017

Pathak G, Agostino M J, Bishara K, Capell W R, Fisher J L, Hegde S, Ibrahim B A, Pilarzyk K, Sabin C, Tuczkewycz T, Wilson S, Kelly M P

Abstract excerpt

Lithium responsivity in patients with bipolar disorder has been genetically associated with Phosphodiesterase 11A (PDE11A), and lithium decreases PDE11A mRNA in induced pluripotent stem cell-derived hippocampal neurons originating from lithium-responsive patients. PDE11 is an enzyme uniquely enriched in the hippocampus that breaks down cyclic AMP and cyclic GMP. Here we determined whether decreasing PDE11A...

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Identifiers

PMID: 27646265
DOI: 10.1038/mp.2016.155
PMCID: PMC5359083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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