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Article

Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.

Genes, brain, and behavior - 1 Nov 2017

Hufgard J R, Williams M T, Vorhees C V

Abstract excerpt

Phosphodiesterase-1b (Pde1b) is highly expressed in striatum, dentate gyrus, CA3 and substantia nigra. In a new Floxed Pde1b × CreCMV global knockout (KO) mouse model, we show an immobility-resistance phenotype that recapitulates that found in constitutive Pde1b KO mice. We use this new mouse model to show that the resistance to acute stress-induced depression-like phenotype is not the product of changes in...

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Identifiers

PMID: 28488329
DOI: 10.1111/gbb.12391
PMCID: PMC5677534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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