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Article

Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.

Biological psychiatry - 15 Aug 2008

Krishnan Vaishnav, Graham Ami, Mazei-Robison Michelle S, Lagace Diane C, Kim Kyoung-Shim, Birnbaum Shari, Eisch Amelia J, Han Pyung-Lim, Storm Daniel R, Zachariou Venetia, Nestler Eric J

Abstract excerpt

BACKGROUND: Adenylyl cyclases (ACs) represent a diverse family of enzymes responsible for the generation of cyclic adenosine monophosphate (cAMP), a key intracellular second messenger. The Ca(2+)/calmodulin-stimulated AC1 and AC8 isoforms as well as the calcium-inhibited AC5 isoform are abundantly expressed within limbic regions of the central nervous system. This study examines the contribution of these AC...

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Identifiers

PMID: 18468583
DOI: 10.1016/j.biopsych.2008.03.026
PMCID: PMC2580057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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