A new model of <i>Pde4d</i> deficiency: genetic knock‐down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects

doi:10.1111/j.1601-183x.2012.00796.x

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Article

A new model of <i>Pde4d</i> deficiency: genetic knock‐down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects

6 Apr 2012

Abstract excerpt

Phosphodiesterases (PDEs) are a superfamily of intracellular second messenger cyclic nucleotide hydrolyzing enzymes composed of 12 families. The Pde4 family has been implicated in depression and cognition, and PDE4 inhibitors have been evaluated as antidepressants and possible cognitive enhancers. Pde4d(-/-) mice show an antidepressant phenotype and learning enhancement on some tests, but not others as do mice...

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PMID: 22487514
DOI: 10.1111/j.1601-183x.2012.00796.x

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