Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.

doi:10.1016/S0893-133X(02)00344-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2002

Zhang Han-Ting, Huang Ying, Jin S-L, Frith Sandra A, Suvarna Neesha, Conti Marco, O'Donnell James M

Abstract excerpt

Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals; however, it is not known which of the four PDE4 subtypes mediates these actions. In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but...

Topics

3',5'-Cyclic-AMP Phosphodiesterases
Adrenergic beta-Agonists
Animals
Antidepressive Agents
Behavior, Animal
Brain
Cyclic AMP
Cyclic Nucleotide Phosphodiesterases, Type 4
Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Down-Regulation

Drug Interactions

Drug Tolerance

Genotype

Male

Mice

Mice, Knockout

Motor Activity

Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 12377395
DOI: 10.1016/S0893-133X(02)00344-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.PMID 12377395Read ↗

A new model of <i>Pde4d</i> deficiency: genetic knock‐down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effectsSemantic proximity Read ↗

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).Semantic proximity Read ↗

RNA interference‐mediated phosphodiesterase 4D splice variants knock‐down in the prefrontal cortex produces antidepressant‐like and cognition‐enhancing effectsSemantic proximity Read ↗

Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test.Semantic proximity Read ↗

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.Semantic proximity Read ↗

Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localizationSemantic proximity Read ↗

Phosphodiesterase 4B: Master Regulator of Brain SignalingSemantic proximity Read ↗

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.Semantic proximity Read ↗

Phosphodiesterase genes and antidepressant treatment response: a review.Semantic proximity Read ↗

PDE11A negatively regulates lithium responsivity.Semantic proximity Read ↗

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.Semantic proximity Read ↗

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.