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Article

Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior.

Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2013

Mineur Yann S, Obayemi Adetokunbo, Wigestrand Mattis B, Fote Gianna M, Calarco Cali A, Li Alice M, Picciotto Marina R

Abstract excerpt

Symptoms of depression can be induced in humans through blockade of acetylcholinesterase (AChE) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ACh) receptors. Thus, ACh signaling could contribute to the etiology of mood regulation. To test this hypothesis, we administered the AChE inhibitor physostigmine to mice and demonstrated...

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Source

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Identifiers

PMID: 23401542
DOI: 10.1073/pnas.1219731110
PMCID: PMC3587265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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