Article

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy

2025-05-17

Abstract excerpt

Despite the availability of nearly 40 approved anti-seizure medications (ASMs), at least one-third of individuals with epilepsy remain refractory to treatment, and many experience life-limiting cognitive or psychiatric side effects. Using a machine learning-guided platform, we identified PDE4 as an underexplored anti-seizure target, which became further validated based on its enriched expression in seizure-relevan...

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Literature Corpus work: 5a2a03f6-6bc0-5fc4-8489-ef85ccb5a043
DOI: 10.1101/2025.05.13.653835

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