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Article

Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.

The Journal of biological chemistry - 8 Jul 2011

Wang Chaojian, Wang Chuan, Hoch Ethan G, Pitt Geoffrey S

Abstract excerpt

Fibroblast growth factor homologous factors (FHFs, FGF11-14) bind to the C termini (CTs) of specific voltage-gated sodium channels (VGSC) and thereby regulate their function. The effect of an individual FHF on a specific VGSC varies greatly depending upon the individual FHF isoform. How individual FHFs impart distinctive effects on specific VGSCs is not known and the specificity of these pairwise interactions is...

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Source

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Identifiers

PMID: 21566136
DOI: 10.1074/jbc.M111.245803
PMCID: PMC3129206

Genes

FGF12
FGF11
FGF13

Variants

Provenance

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