EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.

doi:10.1006/jmbi.1998.2536

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Article

EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.

Journal of molecular biology - 26 Feb 1999

Smallridge R S, Whiteman P, Doering K, Handford P A, Downing A K

Abstract excerpt

Calcium binding epidermal growth factor-like domains (cbEGFs) are present in many extracellular proteins, including fibrillin-1, Notch-3, protein S, factor IX and the low density lipoprotein (LDL) receptor, which perform a diverse range of functions. Genetic mutations that cause amino acid changes within these proteins have been linked to the Marfan syndrome (MFS), CADASIL, protein S deficiency, haemophilia B and...

Topics

Binding Sites
Calcium
Epidermal Growth Factor
Fibrillin-1
Fibrillins
Humans
Magnetic Resonance Spectroscopy
Marfan Syndrome
Microfilament Proteins
Mutation
Phenotype
Protein Binding
Protein Structure, Secondary
Spectrometry, Fluorescence
Tyrosine

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PMID: 10024441
DOI: 10.1006/jmbi.1998.2536

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