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Article

EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.

Journal of molecular biology - 26 Feb 1999

Smallridge R S, Whiteman P, Doering K, Handford P A, Downing A K

Abstract excerpt

Calcium binding epidermal growth factor-like domains (cbEGFs) are present in many extracellular proteins, including fibrillin-1, Notch-3, protein S, factor IX and the low density lipoprotein (LDL) receptor, which perform a diverse range of functions. Genetic mutations that cause amino acid changes within these proteins have been linked to the Marfan syndrome (MFS), CADASIL, protein S deficiency, haemophilia B and...

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Source

Identifiers

PMID: 10024441
DOI: 10.1006/jmbi.1998.2536

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.PMID 10024441Read ↗

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A G1127S change in calcium-binding epidermal growth factor-like domain 13 of human fibrillin-1 causes short range conformational effects.Semantic proximity Read ↗

The calcium binding properties and molecular organization of epidermal growth factor-like domains in human fibrillin-1.Semantic proximity Read ↗

Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.Semantic proximity Read ↗

A Gly --> Ser change causes defective folding in vitro of calcium-binding epidermal growth factor-like domains from factor IX and fibrillin-1.Semantic proximity Read ↗

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Structural consequences of cysteine substitutions C1977Y and C1977R in calcium-binding epidermal growth factor-like domain 30 of human fibrillin-1.Semantic proximity Read ↗

Substitution of a cysteine residue in a non-calcium binding, EGF-like domain of fibrillin segregates with the Marfan syndrome in a large kindred.Semantic proximity Read ↗

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