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Article

Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.

The Journal of biological chemistry - 26 Jun 2009

Goetz Regina, Dover Katarzyna, Laezza Fernanda, Shtraizent Nataly, Huang Xiao, Tchetchik Dafna, Eliseenkova Anna V, Xu Chong-Feng, Neubert Thomas A, Ornitz David M, Goldfarb Mitchell, Mohammadi Moosa

Abstract excerpt

Voltage-gated sodium channels (Nav) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells. Fibroblast growth factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav alpha subunit to modulate fast inactiv...

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Identifiers

PMID: 19406745
DOI: 10.1074/jbc.M109.001842
PMCID: PMC2719427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19406745-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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