Article
Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.
Trends in cardiovascular medicine - 1 Oct 2011
Wei Eric Q, Barnett Adam S, Pitt Geoffrey S, Hennessey Jessica A
Abstract excerpt
The four fibroblast growth factor homologous factors (FHFs; FGF11-FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs). Although FHFs have been well studied in neurons and implicated in neurologic disease, their role in cardiomyocytes was unclear until recently. This review discusses the expression profile and function of FHFs in mouse and rat ventricular cardiomyocytes....
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