Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Oct 2007

Laezza Fernanda, Gerber Benjamin R, Lou Jun-Yang, Kozel Marie A, Hartman Hali, Craig Ann Marie, Ornitz David M, Nerbonne Jeanne M

Abstract excerpt

Fibroblast growth factor 14 (FGF14) belongs to the intracellular FGF homologous factor subfamily of FGF proteins (iFGFs) that are not secreted and do not activate tyrosine kinase receptors. The iFGFs, however, have been shown to interact with the pore-forming (alpha) subunits of voltage-gated Na+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Radiation
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to Ion Channel Gating

Share to Phenylalanine

Share to Sodium Channel Blockers

Share to Sodium Channels

Share to Tetrodotoxin

Source

Open in PubMed Open full text

Identifiers

PMID: 17978045
DOI: 10.1523/JNEUROSCI.2282-07.2007
PMCID: PMC6673376

Genes

FGF14

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17978045-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.PMID 17978045Read ↗

Fibroblast growth factor 14 is an intracellular modulator of voltage‐gated sodium channelsSemantic proximity Read ↗

In Vivo Expression of an SCA27A-Linked FGF14 Mutation Results in Haploinsufficiency and Impaired Firing of Cerebellar Purkinje Neurons.Semantic proximity Read ↗

FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.Semantic proximity Read ↗

Modulating effects of <i>FGF12</i> variants on Na <sub>V</sub> 1.2 and Na <sub>V</sub> 1.6 associated with Developmental and Epileptic Encephalopathy and Autism Spectrum DisorderSemantic proximity Read ↗

Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27Semantic proximity Read ↗

Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.Semantic proximity Read ↗

Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.Semantic proximity Read ↗

A new variable phenotype in spinocerebellar ataxia 27 (SCA 27) caused by a deletion in the FGF14 gene.Semantic proximity Read ↗

Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.Semantic proximity Read ↗

Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13.Semantic proximity Read ↗

Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.Semantic proximity Read ↗

Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.