Article
Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.
Circulation research - 16 Sept 2011
Wang Chuan, Hennessey Jessica A, Kirkton Robert D, Wang Chaojian, Graham Victoria, Puranam Ram S, Rosenberg Paul B, Bursac Nenad, Pitt Geoffrey S
Abstract excerpt
RATIONALE: Fibroblast growth factor homologous factors (FHFs), a subfamily of fibroblast growth factors (FGFs) that are incapable of functioning as growth factors, are intracellular modulators of Na(+) channels and have been linked to neurodegenerative diseases. Although certain FHFs have been found in embryonic heart, they have not been reported in adult heart, and they have not been shown to regulate endogenous...
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