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Article

Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality.

The Prostate - 1 Feb 2012

Shui Irene M, Stark Jennifer R, Penney Kathryn L, Schumacher Fredrick R, Epstein Mara M, Pitt Michael J, Stampfer Meir J, Tamimi Rulla M, Lindstrom Sara, Sesso Howard D, Fall Katja, Ma Jing, Kraft Peter, Giovannucci Edward, Mucci Lorelei A

Abstract excerpt

BACKGROUND: Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer. METHODS: In a large nested case-control study of prostate cancer in the Physicians' Health Study (1982-2004), 10 single nucleotide polymorphisms (SNPs) were selected and genotyped to capture common variation within the TLR4 gene as well as...

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Identifiers

PMID: 21563195
DOI: 10.1002/pros.21423
PMCID: PMC3175021

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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