Article
Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study.
Cancer research - 15 Apr 2004
Zheng S Lilly, Augustsson-Bälter Katarina, Chang Baoli, Hedelin Maria, Li Liwu, Adami Hans-Olov, Bensen Jeanette, Li Ge, Johnasson Jan-Erik, Turner Aubrey R, Adams Tamara S, Meyers Deborah A, Isaacs William B, Xu Jianfeng, Grönberg Henrik
Abstract excerpt
Inflammation has been implicated as an etiological factor in several human cancers. Growing evidence suggests that chronic inflammation may also play a role in the etiology of prostate cancer. Considering that genetic susceptibility is a major risk factor for this disease, we hypothesize that sequence variants in genes that regulate inflammation may modify individual susceptibility to prostate cancer. The...
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