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Article

Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer.

Cancer research - 15 Dec 2005

Chen Yen-Ching, Giovannucci Edward, Lazarus Ross, Kraft Peter, Ketkar Shamika, Hunter David J

Abstract excerpt

Chronic inflammation has been hypothesized to be a risk factor for prostate cancer. The Toll-like receptor 4 (TLR4) presents the bacterial lipopolysaccharide (LPS), which interacts with ligand-binding protein and CD14 (LPS receptor) and activates expression of inflammatory genes through nuclear factor-kappaB and mitogen-activated protein kinase signaling. A previous case-control study found a modest association...

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Identifiers

PMID: 16357190
DOI: 10.1158/0008-5472.CAN-05-2078

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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