Article
Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
PloS one - 1 Jan 2014
Weng Pei-Hsuan, Huang Yi-Ling, Page John H, Chen Jen-Hau, Xu Jianfeng, Koutros Stella, Berndt Sonja, Chanock Stephen, Yeager Meredith, Witte John S, Eeles Rosalind A, Easton Douglas F, Neal David E, Donovan Jenny, Hamdy Freddie C, Muir Kenneth R, Giles Graham, Severi Gianluca, Smith Jeffrey R, Balistreri Carmela R, Shui Irene M, Chen Yen-Ching
Abstract excerpt
BACKGROUND: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the...
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