Article
Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.
International journal of cancer - 1 Dec 2008
Stevens Victoria L, Hsing Ann W, Talbot Jeffrey T, Zheng Siqun Lilly, Sun Jielin, Chen Jinbo, Thun Michael J, Xu Jianfeng, Calle Eugenia E, Rodriguez Carmen
Abstract excerpt
Toll-like receptors (TLRs) are key players in the innate immune system and initiate the inflammatory response to foreign pathogens such as bacteria, fungi and viruses. The proposed role of chronic inflammation in prostate carcinogenesis has prompted investigation into the association of common genetic variation in TLRs with the risk of this cancer. We investigated the role of common SNPs in a gene cluster...
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