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Article

Meis2 as a critical player in MN1-induced leukemia

29 Sept 2017

Abstract excerpt

Meningioma 1 (MN1) is an independent prognostic marker for normal karyotype acute myeloid leukemia (AML), with high expression linked to all-trans retinoic acid resistance and poor survival. MN1 is also a potent and sufficient oncogene in murine leukemia models, strongly dependent on the MEIS1/AbdB-like HOX protein complex to transform common myeloid progenitors, block myeloid differentiation, and promote...

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PMID: 28960191
DOI: 10.1038/bcj.2017.86

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