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Helicobacter pylori ‐induced DNA double‐stranded break in the development of gastric cancer

31 Mar 2022

Abstract excerpt

Infection with cagA-positive Helicobacter pylori strains plays an etiological role in the development of gastric cancer. The CagA protein is injected into gastric epithelial cells through a bacterial Type IV secretion system. Inside the host cells, CagA promiscuously associates with multiple host cell proteins including the prooncogenic phosphatase SHP2 that is required for full activation of the Ras-ERK pathway....

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PMID: 35359025
DOI: 10.1111/cas.15357

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