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Article

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Science (New York, N.Y.) - 25 Jan 2002

Higashi Hideaki, Tsutsumi Ryouhei, Muto Syuichi, Sugiyama Toshiro, Azuma Takeshi, Asaka Masahiro, Hatakeyama Masanori

Abstract excerpt

Helicobacter pylori CagA protein is associated with severe gastritis and gastric carcinoma. CagA is injected from the attached Helicobacter pylori into host cells and undergoes tyrosine phosphorylation. Wild-type but not phosphorylation-resistant CagA induced a growth factor-like response in gastric epithelial cells. Furthermore, CagA formed a physical complex with the SRC homology 2 domain (SH2)-containing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11743164
DOI: 10.1126/science.1067147

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SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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