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Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells

5 Apr 2020

Abstract excerpt

Approximately half of the world's population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori-infected individuals develop gastric cancer. This raises the question of defining the...

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PMID: 32250340
DOI: 10.1172/jci130015

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