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Article

Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma.

PloS one - 29 Apr 2011

Minmin Shi, Xiaoqian Xu, Hao Chen, Baiyong Shen, Xiaxing Deng, Junjie Xie, Xi Zhan, Jianquan Zhao, Songyao Jiang

Abstract excerpt

BACKGROUND: Toll-like receptor 4 (TLR4) is a key innate immunity receptor that initiates an inflammatory response. Growing evidence suggests that mutation of TLR4 gene may play a role in the development of cancers. This study aimed to investigate the temporal relationship of single nucleotide polymorphisms of TLR4 and the risk of hepatocellular carcinoma, a single center-based case-control study was conducted....

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Identifiers

PMID: 21559380
DOI: 10.1371/journal.pone.0019466
PMCID: PMC3084862

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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