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Article

Impact of Toll-like receptor 4 polymorphisms on risk of cancer.

Human immunology - 1 Feb 2011

Kutikhin Anton G

Abstract excerpt

Toll-like receptor 4 (TLR4) is one of the key immune system effectors playing the main role in recognition of viruses and bacteria. Dysregulation of the TLR4 signaling owing to single nucleotide polymorphisms (SNPs) may alter the ligand binding and balance between pro- and anti-inflammatory cytokines, thereby modulating the risk of chronic inflammation and cancer. TLR4 polymorphisms may be associated with at...

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Source

Identifiers

PMID: 21081146
DOI: 10.1016/j.humimm.2010.11.003

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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