A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.

doi:10.1007/s13277-014-2547-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014

Jiang Zi-Cheng, Tang Xian-Mei, Zhao Ying-Ren, Zheng Lei

Abstract excerpt

Toll-like receptor 4 (TLR4) plays a key role in prompting the innate or immediate response. A growing body of evidence suggests that genetic variants of TLR4 gene were associated with the development of cancers. This study aimed to investigate the relationship of a functional variant (rs1057317) at microRNA-34a (miR-34a) binding site in toll-like receptor 4 gene and the risk of hepatocellular carcinoma. A single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Carcinoma, Hepatocellular

Share to Liver Neoplasms

Share to MicroRNAs

Share to Odds Ratio

Share to RNA Interference

Share to Toll-Like Receptor 4

Source

Open in PubMed

Identifiers

PMID: 25179842
DOI: 10.1007/s13277-014-2547-z

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.PMID 25179842Read ↗

Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma.Semantic proximity Read ↗

Single Nucleotide Polymorphisms of Toll-like Receptor 4 in Hepatocellular Carcinoma-A Single-Center Study.Semantic proximity Read ↗

Role of toll-like receptors gene polymorphism in hepatocellular carcinoma.Semantic proximity Read ↗

Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.Semantic proximity Read ↗

Analysis of the genetic diversity in TLR4 3'-untranslated region among Asian populations and the biological effects of altofrequent SNPsSemantic proximity Read ↗

Toll-like receptor 4 gene polymorphism downregulates gene expression and involves in susceptibility to bladder cancer.Semantic proximity Read ↗

Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development.Semantic proximity Read ↗

An updated systematic review of the association between the TLR4 polymorphism rs4986790 and cancers risk.Semantic proximity Read ↗

Functional significance of the TLR4/11367 polymorphism identified in Chinese Han population.Semantic proximity Read ↗

TLR4 promoter rs1927914 variant contributes to the susceptibility of esophageal squamous cell carcinoma in the Chinese populationSemantic proximity Read ↗

Impact of Toll-like receptor 4 polymorphisms on risk of cancer.Semantic proximity Read ↗

Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.