Article
Role of toll-like receptors gene polymorphism in hepatocellular carcinoma.
Journal of receptor and signal transduction research - 1 Oct 2014
Lin Wei, Chen Jinkun, Zhu Bo, Xu Xiling, Dong Zhiyong
Abstract excerpt
Toll-like receptors (TLRs), evolutionarily conserved innate, play important roles in the development of autoimmunity. TLRs proteins are localized on the cell surface or in endosomes and play critical roles in innate immune responses against different pathogens. Aberrant stimulation of the innate immune system through intracellular TLRs may lead to hyperactive immune responses and contribute to the pathogenesis of...
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