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Article

α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.

Nature communications - 1 Jan 2011

He Lizhi, Fan Catherine, Kapoor Anil, Ingram Alistair J, Rybak Adrian P, Austin Richard C, Dickhout Jeffery, Cutz Jean-Claude, Scholey James, Tang Damu

Abstract excerpt

PTEN dephosphorylates the 3-position phosphate of phosphatidylinositol 3,4,5 triphosphate (PIP(3)), thereby inhibiting AKT activation. Although attenuation of PTEN function has a major role in tumourigenesis, the underlying mechanisms remain unclear. Here we show that α-mannosidase 2C1 (MAN2C1) inhibits PTEN function in prostate cancer (PC) cells and is associated with a reduction in PTEN function in primary PC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21556061
DOI: 10.1038/ncomms1309

Genes

PTEN
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.PMID 21556061Read ↗

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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.Semantic proximity Read ↗

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