Article
Prostate cancer, PI3K, PTEN and prognosis.
Clinical science (London, England : 1979) - 1 Feb 2017
Wise Helen M, Hermida Miguel A, Leslie Nicholas R
Abstract excerpt
Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most common driving events in prostate cancer development. The observed mechanisms of PTEN loss are diverse, but both homozygous and heterozygous genomic deletions including PTEN are frequent, and often accompanied by loss of detectable...
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