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Article

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Nature communications - 15 Nov 2017

Wozniak Darren J, Kajdacsy-Balla Andre, Macias Virgilia, Ball-Kell Susan, Zenner Morgan L, Bie Wenjun, Tyner Angela L

Abstract excerpt

PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate cancer cell line leads to dephosphorylation of PY342 but not PY447 and PTK6 inhibition. Conversely, PTEN knockdown...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Neoplasm Proteins

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Share to Protein-Tyrosine Kinases

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Source

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Identifiers

PMID: 29142193
DOI: 10.1038/s41467-017-01574-5
PMCID: PMC5688148

Genes

PTEN
PTK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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