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Article

Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress.

Hormones and behavior - 1 Mar 2020

Eid Rand S, Lieblich Stephanie E, Duarte-Guterman Paula, Chaiton Jessica A, Mah Amanda G, Wong Sarah J, Wen Yanhua, Galea Liisa A M

Abstract excerpt

The estrogen receptor (ER) mechanisms by which 17β-estradiol influences depressive-like behaviour have primarily been investigated acutely and not within an animal model of depression. Therefore, the current study aimed to dissect the contribution of ERα and ERβ to the effects of 17β-estradiol under non-stress and chronic stress conditions. Ovariectomized (OVX) or sham-operated mice were treated chronically...

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Identifiers

PMID: 31790664
DOI: 10.1016/j.yhbeh.2019.104651

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