Article
Absent LH signaling rescues the anxiety phenotype in aging female mice.
Molecular psychiatry - 1 Aug 2023
Sims Steven, Barak Orly, Ryu Vitaly, Miyashita Sari, Kannangara Hasni, Korkmaz Funda, Wizman Soleil, Macdonald Anne, Gumerova Anisa, Goosens Ki, Zaidi Mone, Yuen Tony, Lizneva Daria, Frolinger Tal
Abstract excerpt
Clinical studies and experimental data together support a role for pituitary gonadotropins, including luteinizing hormone (LH), otherwise considered solely as fertility hormones, in age-related cognitive decline. Furthermore, rising levels of LH in post-menopausal women have been implicated in the high prevalence of mood disorders. This study was designed to examine the effect of deficient LH signaling on both...
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