Article
p53 expression in patients with cirrhosis with and without hepatocellular carcinoma.
Cancer - 15 May 1995
Livni N, Eid A, Ilan Y, Rivkind A, Rosenmann E, Blendis L M, Shouval D, Galun E
Abstract excerpt
BACKGROUND: Mutated p53 acts as a dominant oncogene, whereas the wild type (wt) p53 gene product suppresses cell growth. Abnormalities in the p53 gene are reported in more than 50% of malignant tumors. Recently, an allelic loss of chromosome 17p, where the p53 gene is located, was found to be more frequent in hepatocellular carcinoma (HCC) cell lines and human tumors. In addition, in half of the cases of HCC from...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
- Child
- Child, Preschool
- Female
- Gene Expression Regulation
- Gene Expression Regulation, Neoplastic
- Genes, p53