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Article

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

Cancer research - 15 Oct 1991

Murakami Y, Hayashi K, Hirohashi S, Sekiya T

Abstract excerpt

Aberrations of the p53 gene in 43 primary hepatocellular carcinomas (HCCs) were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products. Of these hepatocellular carcinomas, 22 were advanced HCCs, and 21 were early HCCs. Structural abnormalities of the p53 gene were observed in eight of the 22 advanced HCCs, but in none of the early HCCs. Of the eight tumors with an...

Topics

Base Sequence
Carcinoma, Hepatocellular
Chromosomes, Human, Pair 17
Codon
Exons
Genes, Retinoblastoma
Genes, p53
Humans
Liver Neoplasms
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Source

Identifiers

PMID: 1655254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655254-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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