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New Insights on the Nuclear Functions and Targeting of FAK in Cancer

11 Feb 2022

Abstract excerpt

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed and activated in both adult and pediatric cancers, where it plays important roles in the regulation of pathogenesis and progression of the malignant phenotype. FAK exerts its functions in cancer by two different ways: a kinase activity in the cytoplasm, mainly dependent on the integrin signaling, and a scaffolding activity into the...

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PMID: 35216114
DOI: 10.3390/ijms23041998

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