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Article

Serotonin transporter genotype x construction stress interaction in rats.

Behavioural brain research - 30 Sept 2011

Schipper Pieter, Nonkes Lourens J P, Karel Peter, Kiliaan Amanda J, Homberg Judith R

Abstract excerpt

A well-known example for gene x environment interactions in psychiatry is the one involving the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism (5-HTTLPR) that in the context of stress increases risk for depression. In analogy, 5-HTT knockout rodents are highly responsive to early life, but also adult external stressors, albeit conflicting data have been obtained. In...

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Source

Identifiers

PMID: 21549766
DOI: 10.1016/j.bbr.2011.04.037

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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