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Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood.

Behavioural brain research - 11 Feb 2010

Jansen Friederike, Heiming Rebecca S, Lewejohann Lars, Touma Chadi, Palme Rupert, Schmitt Angelika, Lesch Klaus Peter, Sachser Norbert

Abstract excerpt

Behavioural profiles can be shaped by genotype and environmental factors during early phases of life. The aim of this study was to investigate whether anxiety-like behaviour, exploration and adrenocortical stress responses can be modulated by genotype and social experiences in adulthood. Male mice lacking the serotonin transporter gene which is under scrutiny for anxiety disorders were compared with heterozygous...

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Identifiers

PMID: 19782704
DOI: 10.1016/j.bbr.2009.09.033

Genes

HTT

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