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Article

Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype.

Behavioural brain research - 15 Jun 2013

Kloke Vanessa, Heiming Rebecca S, Bölting Stefanie, Kaiser Sylvia, Lewejohann Lars, Lesch Klaus-Peter, Sachser Norbert

Abstract excerpt

Developmental mechanisms that shape behaviour are under environmental as well as genetic influence, commonly referred to as gene-by-environment interaction (GxE). Here, we compared the role of different early environments - adverse, standard, and enriched - for the modulation of the anxiety profile in mice varying in serotonin transporter (5-HTT) genotype. Early-life adversity was simulated by exposing lactating...

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Identifiers

PMID: 23567893
DOI: 10.1016/j.bbr.2013.03.039

Genes

HTT

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