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Article

Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression.

Biological psychiatry - 1 May 2008

Carola Valeria, Frazzetto Giovanni, Pascucci Tiziana, Audero Enrica, Puglisi-Allegra Stefano, Cabib Simona, Lesch Klaus-Peter, Gross Cornelius

Abstract excerpt

BACKGROUND: A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understanding of this phenomenon is lacking. Such an understanding might help to identify novel targets for...

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Source

Identifiers

PMID: 17949690
DOI: 10.1016/j.biopsych.2007.08.013

Genes

HTT
BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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