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Article

Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice.

PloS one - 1 Jan 2011

Narayanan Venu, Heiming Rebecca S, Jansen Friederike, Lesting Jörg, Sachser Norbert, Pape Hans-Christian, Seidenbecher Thomas

Abstract excerpt

Emotions, such as fear and anxiety, can be modulated by both environmental and genetic factors. One genetic factor is for example the genetically encoded variation of the serotonin transporter (5-HTT) expression. In this context, the 5-HTT plays a key role in the regulation of central 5-HT neurotransmission, which is critically involved in the physiological regulation of emotions including fear and anxiety....

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Source

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Identifiers

PMID: 21818344
DOI: 10.1371/journal.pone.0022600
PMCID: PMC3144906

Genes

HTT

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