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Article

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Molecular cell - 6 May 2011

Caballero Antonio, Ugidos Ana, Liu Beidong, Öling David, Kvint Kristian, Hao Xinxin, Mignat Cora, Nachin Laurence, Molin Mikael, Nyström Thomas

Abstract excerpt

Altered mitochondrial functionality can extend organism life span, but the underlying mechanisms are obscure. Here we report that inactivating SOV1, a member of the yeast mitochondrial translation control (MTC) module, causes a robust Sir2-dependent extension of replicative life span in the absence of respiration and without affecting oxidative damage. We found that SOV1 interacts genetically with the cAMP-PKA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 21549315
DOI: 10.1016/j.molcel.2011.03.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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