DNA replication stress-induced loss of reproductive capacity in<i>S. cerevisiae</i>and its inhibition by caloric restriction

Abstract excerpt

In many organisms, attenuation of growth signaling by caloric restriction or mutational inactivation of growth signaling pathways extends lifespan and protects against cancer and other age-related diseases. The focus of many efforts to understand these effects has been on the induction of oxidative stress defenses that inhibit cellular senescence and cell death. Here we show that in the model organism S....

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