Article
Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism.
Cell cycle (Georgetown, Tex.) - 1 Nov 2006
Noble Daniel, Kenna Margaret A, Dix Melissa, Skibbens Robert V, Unal Elçin, Guacci Vincent
Abstract excerpt
Sister chromatid cohesion is established during S phase and maintained until anaphase. The cohesin complex (Mcd1p/Scc1p, Smc1p, Smc3p Irr1p/Scc3p in budding yeast) serves a structural role as it is required at all times when cohesion exists. Pds5p colocalizes temporally and spatially with cohesin on chromosomes but is thought to serve as a regulator of cohesion maintenance during mitosis. In contrast, Ctf7p/Eco1p...
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