Article
Evidence for the contribution of NOS1 gene polymorphism (rs3782206) to prefrontal function in schizophrenia patients and healthy controls.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2015
Zhang Zhifang, Chen Xiongying, Yu Ping, Zhang Qiumei, Sun Xiaochen, Gu Huang, Zhang Hao, Zhai Jinguo, Chen Min, Du Boqi, Deng Xiaoxiang, Ji Feng, Wang Chuanyue, Xiang Yutao, Li Dawei, Wu Hongjie, Li Jun, Dong Qi, Chen Chuansheng
Abstract excerpt
Nitric oxide (NO), a gaseous neurotransmitter, has been implicated in the pathogenesis of schizophrenia. Accordingly, several polymorphisms of the gene that codes for the main NO-producing enzyme, the nitric oxide synthase 1 (NOS1), have been found to convey a risk for schizophrenia. This study examined the role of NOS1 gene polymorphisms in cognitive functions and related neural mechanism. First, with a sample...
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