Article
Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals.
Human brain mapping - 1 Oct 2009
Kircher Tilo, Krug Axel, Markov Valentin, Whitney Carin, Krach Sören, Zerres Klaus, Eggermann Thomas, Stöcker Tony, Shah Nadim Jon, Treutlein Jens, Nöthen Markus M, Becker Tim, Rietschel Marcella
Abstract excerpt
Impaired performance in verbal fluency tasks is an often replicated finding in schizophrenia. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and temporal areas. Since schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such as NRG1, modulate verbal fluency performance and its neural correlates. Four hundred...
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