Article
Low probability of double integration in transformation of nonpermissive cells by polyomavirus.
Journal of virology - 1 Mar 1990
Oh S Y, Amalfitano A, Friderici K, Chen M C, Fluck M M
Abstract excerpt
The fate of polyomavirus genomes in stable transformants was examined in experiments in which rat or hamster cells were infected with mixed viral populations containing either two distinguishable wild types or a wild type plus a transformation-deficient mutant. The results demonstrate that in 90% of the cases in either situation, a single polyomavirus parental genome became integrated into the host genome. Both...
Topics
- Animals
- Cell Line
- Cell Transformation, Viral
- Chromosome Deletion
- Cricetinae
- Genes, Viral
- Lysogeny
- Mutation
- Polyomavirus
- Probability
- Rats