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Article

Amplification of polyomavirus DNA sequences stably integrated in rat cells.

Nucleic acids research - 11 Dec 1991

St-Onge L, Bastin M

Abstract excerpt

To investigate the mechanism by which the polyomavirus large T antigen (T-Ag) promotes amplification of integrated viral sequences, we constructed a rat cell line, Hy2-ts5, carrying two different inserts of polyomavirus DNA. The first insert, designated the middle T (pmt) locus, was devised to analyze homologous recombination between two defective copies of pmt lying 3.3 kb apart on the same chromosome....

Topics

Animals
Antigens, Viral, Tumor
Blotting, Southern
Cell Line
DNA, Viral
Gene Amplification
Models, Genetic
Mutation
Polyomavirus
Rats
Recombination, Genetic
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1661409
DOI: 10.1093/nar/19.23.6619
PMCID: PMC329231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1661409-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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