Enhancer-mediated role for polyomavirus middle T/small T in DNA replication.

doi:10.1128/JVI.69.1.326-333.1995

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Article

Enhancer-mediated role for polyomavirus middle T/small T in DNA replication.

Journal of virology - 1 Jan 1995

Chen M C, Redenius D, Osati-Ashtiani F, Fluck M M

Abstract excerpt

A major role for polyomavirus middle T/small T antigens in viral DNA synthesis was uncovered by examining the replication of middle T/small T-deficient mutants (hr-t mutants). hr-t mutants in the A2 genetic background showed a 16- to 100-fold defect in genome accumulation relative to the wild typ...

Topics

3T3 Cells
Animals
Antigens, Polyomavirus Transforming
DNA Replication
DNA, Viral
Enhancer Elements, Genetic
Genome, Viral
Mice
Mutation
Polyomavirus
Transcription, Genetic

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