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Article

Enhancer-mediated role for polyomavirus middle T/small T in DNA replication.

Journal of virology - 1 Jan 1995

Chen M C, Redenius D, Osati-Ashtiani F, Fluck M M

Abstract excerpt

A major role for polyomavirus middle T/small T antigens in viral DNA synthesis was uncovered by examining the replication of middle T/small T-deficient mutants (hr-t mutants). hr-t mutants in the A2 genetic background showed a 16- to 100-fold defect in genome accumulation relative to the wild type when infections were carried out in exponentially growing NIH 3T3 cells in medium supplemented with low levels of...

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Identifiers

PMID: 7983726
DOI: 10.1128/JVI.69.1.326-333.1995
PMCID: PMC188579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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