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Article

High-frequency recombination mediated by polyomavirus large T antigen defective in replication.

Journal of virology - 1 Apr 1993

St-Onge L, Bouchard L, Bastin M

Abstract excerpt

We investigated the mechanism by which the large T antigen (T-Ag) of both polyomavirus and simian virus 40 (SV40) promotes homologous recombination in mammalian cells. To this end, we constructed a rat cell line, designated Hy5, that carries two mutated copies of the polyomavirus middle-T-Ag (pmt) oncogene lying as direct repeats on the same chromosome. The structure of the viral insert was devised so that...

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Identifiers

PMID: 8445711
DOI: 10.1128/JVI.67.4.1788-1795.1993
PMCID: PMC240224

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Source receipt: pubmed, retrieved 7 Sept 2026.

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